Serum selenoprotein P concentrations and cardiovascular disease: results from a large, prospective cohort study of older German adults

Low serum SELENOP concentrations were associated with an increased risk of stroke in subjects free of CVD and with CVD mortality among CVD patients. The association of SELENOP concentrations with CVD incidence was restricted to patients with hypertension or diabetes. Well-designed trials are required to assess potential preventive effects of selenium supplementation.