Biomineralized Engineered Bacterial Outer Membrane Vesicles as cGAS-STING Nanoagonists Synergize with Lactate Metabolism Modulation to Potentiate Immunotherapy

studies demonstrate that the combined activation of the cGAS-STING pathway and regulation of LA metabolism effectively inhibit primary tumor growth and metastatic progression, highlighting the potential of this synergistic strategy for advancing antitumor immunotherapy.