Mixed Methods Research in the Field of Clinical Practice Guidelines: The Case of Developing a Methodological Model for Good Practice Recommendation

Mixed methods research provides a valuable opportunity to deepen our understanding of phenomena. However, practical guidance on using the method to develop methodological models in clinical practice guidelines (CPGs) field is limited. This article illustrates the use of exploratory sequential mixed methods design to develop a methodological model to standardize the formation of good practice recommendation (GPR) within CPGs in the context of weak evidence or no evidence. It demonstrates how qualitative and quantitative data can be systematically integrated throughout the model construction and validation. The GPR methodological model includes three main themes: connotation , procedure and methods , and reporting guideline . It assists CPGs developers in GPR formulation, aligns researchers’ methodological understanding of GPR, and informs future GPR methodological development.