Nrf2/STAT3-mediated activation of SLC6A3 underlies the neuroprotective effect of quercetin in ischemic stroke

Our findings identify the Nrf2/STAT3/SLC6A3 axis as a key mediator of quercetin's neuroprotective effects in ischemic stroke. To our knowledge, this is the first study to identify the Nrf2/STAT3/SLC6A3 axis as a key regulatory pathway underlying the neuroprotective action of quercetin.