细胞外基质
生物
胰腺癌
上睑下垂
癌症研究
细胞外
癌症
细胞生物学
细胞凋亡
遗传学
程序性细胞死亡
作者
Jian Zhang,Shengnan Lv,Xinyu Peng,Huan Liu,Jianxiong Guo,Ziyu Liu,Tongjia Chu,Han Liu,Kehang Duan,Fengxiang Lou,Yubo Chi,Bing Gao,Yan Liu,Feng Wei
出处
期刊：Molecular Cancer
[BioMed Central]
日期：2025-07-02
卷期号：24 (1): 185-185
被引量：10
标识
DOI：10.1186/s12943-025-02385-9
摘要
Our findings reveal a novel circERC1 as a key regulator in PDAC-secreted EVs following paclitaxel (PTX) treatment, thereby inhibiting gemcitabine/Nab-paclitaxel (GEM-NabP) induced pyroptosis. Our results highlight a potential therapeutic target for overcoming chemoresistance and remodeling pancreatic TME.
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(2025-6-4)
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