溶菌酶
咪唑酯
沸石咪唑盐骨架
化学
药品
组合化学
抗菌活性
两亲性
纳米复合材料
共聚物
纳米技术
材料科学
聚合物
生物化学
有机化学
金属有机骨架
细菌
吸附
药理学
医学
遗传学
生物
作者
Sarmistha Saha,Abhijit Mishra
出处
期刊:Biomaterials Science
[The Royal Society of Chemistry]
日期:2023-01-01
卷期号:11 (2): 481-488
被引量:3
摘要
We developed a strategy to use lysozyme (Lys) as a template to produce mesoporous zeolitic imidazolate framework (ZIF-8) structures under physiological conditions. Thereafter, an amphiphilic triblock copolymer, PEG-PPG-PEG, was used to form protective core-shell ZIF-8 nanocomposite coatings to protect the encapsulated drug epigallocatechin-3-gallate (EGCG), to achieve notable antibacterial properties against E. coli, S. aureus and MRSA strains. Moreover, nanocomposites exhibited anti-inflammatory activity by counteracting the secretion of cytokines in THP-1 macrophages.
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