POLOXAMER 407-INDUCED CHRONIC HYPERLIPIDEMIA IS NOT ASSOCIATED WITH DISORDERS OF BLOOD GLUCOSE LEVELS

PURPOSE: The aim of the study was to evaluate the effects of chronic poloxamer 407 treatment on some parameters of lipid and glucose metabolism in a rat experimental model and to test the potential of this treatment to induce a condition similar to diabetes type 2. METHODS: The following parameters of lipid and glucose metabolism were measured: blood concentration of total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, very low-density lipoprotein (VLDL) cholesterol, triglycerides and glucose concentrations following intravenous glucose tolerance test (IVGTT). Twelve male Wistar rats were used in the study. Rats were divided into two groups: 1) group C (control group) – rats from this group received no treatment during the entire experimental period; 2) group P (poloxamer group) – rats from this group were treated daily with poloxamer for a period of one month after which parameters of lipid and glucose metabolism were measured in both groups. RESULTS: Chronic poloxamer treatment induced significant changes in lipid metabolism parameters but did not affect glucose metabolism parameters. CONCLUSIONS: A 30 days experimental poloxamer treatment in rats is not associated with disorders of blood glucose levels.