磷酸西他列汀
医学
心肾综合症
糖尿病
2型糖尿病
磷酸西他列汀
2型糖尿病
内科学
重症监护医学
内分泌学
心力衰竭
作者
Parag S. Shah,Mangesh Tiwaskar,Ameya Joshi,Bharadwaja Pendurthi,Shruti Dharmadhikari,Prachi Ahire,Chintan Khandhedia,Neeraj Markandeywar,Amey Mane,Suyog Mehta
出处
期刊:PubMed
日期:2025-04-01
卷期号:73 (4): e19-e25
标识
DOI:10.59556/japi.73.0924
摘要
Type 2 diabetes (T2D) is a major public health problem globally, with significant socioeconomic ramifications for healthcare systems. Diabetes unquestionably contributes to both cardiovascular disease (CVD) and chronic renal disease. Hospitalization, low quality of life, and high mortality rate are inevitable in patients with this dual burden. As a result, the emphasis in diabetes care should also be on cardiorenal health. Glycemic control, as well as optimal management of cardiorenal risk factors and comorbidities, is required to eliminate cardiovascular (CV) morbidity and mortality related to T2D. Sitagliptin is a highly efficient and selective dipeptidyl peptidase-4 inhibitor (DPP-4i) that improves glycemic control while having a low risk of hypoglycemia. It has neutral effects on body weight, low proclivity for pharmacokinetic interactions, and a favorable safety profile. Numerous clinical trials have proven that sitagliptin is CV- and renal-safe in T2D patients, even in those with obesity, old age, renal impairment (RI), and preexisting CVD. It also corrects hyperglycemia-induced osmotic diuresis and excessive filtration. In people with T2D who are at high CV risk or moderate-to-severe renal insufficiency, sitagliptin is documented as a well-tolerated treatment that does not augment the risk of CV and renal complications. Sitagliptin may effectively manage CV and renal complications in diabetes patients, considering its CV and renal safety.
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