Solid‐Phase Extraction Coupled to Tandem Mass Spectrometry for Rapid Quantitation of Urinary Catecholamines and Total Metanephrines

SPE coupled with pulsed-dc-ESI-MS/MS demonstrated improved efficiency compared to existing methods, which successfully enabled the rapid screening of urinary catecholamines and total metanephrines. Therefore, we believe that this method could be potentially useful in the clinical screening of PPGL and suitable for the direct analysis of urine.