Role of Stress-Responsive NR4A2 in Aldosterone-Producing Cell Cluster Formation

Our findings suggest that NR4A2 activation in ZG cells functions as a key molecular mediator in stress-induced APCC formation at least in some cases. Some APCCs maintained ZG-like characteristics with heightened stress responsiveness, representing a distinct cellular state from aldosterone-producing adenomas, which exhibit metabolic reprogramming and enhanced energy metabolism.