Tuning of cellular insulin release by music for real-time diabetes control

Music consists of acoustic waves that are converted by the bony ossicles in the middle ear into mechanical vibrations. These vibrations activate mechanosensitive ion channels in hair cells,1 causing membrane depolarisation and release of neurotransmitters, thereby influencing human emotion. Similar mechanosensitive ion channels are ubiquitous across all kingdoms of life. Examples include transient receptor potential channels,2 piezo-type mechanosensitive ion channels (eg, Piezo1 and Piezo2),3 bacterial small conductance mechanosensitive channels (MscS), and large conductance mechanosensitive channels (MscL).