内质网
未折叠蛋白反应
自噬
慢性阻塞性肺病
炎症
细胞生物学
肺病
医学
平衡
蛋白质折叠
免疫学
生物信息学
细胞凋亡
化学
生物
内科学
生物化学
作者
Yue Yu,Ailin Yang,Ganggang Yu,Haoyan Wang
出处
期刊:Biomolecules
[MDPI AG]
日期:2022-11-04
卷期号:12 (11): 1637-1637
摘要
The endoplasmic reticulum (ER) is an integral organelle for maintaining protein homeostasis. Multiple factors can disrupt protein folding in the lumen of the ER, triggering ER stress and activating the unfolded protein response (UPR), which interrelates with various damage mechanisms, such as inflammation, apoptosis, and autophagy. Numerous studies have linked ER stress and UPR to the progression of chronic obstructive pulmonary disease (COPD). This review focuses on the mechanisms of other cellular processes triggered by UPR and summarizes drug intervention strategies targeting the UPR pathway in COPD to explore new therapeutic approaches and preventive measures for COPD.
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