T细胞受体
生物
CD8型
细胞毒性T细胞
T细胞
免疫疗法
抗原
免疫系统
癌症免疫疗法
链霉菌
免疫学
计算生物学
遗传学
体外
出处
期刊:eLife
[eLife Sciences Publications, Ltd.]
日期:2022-11-09
卷期号:11
摘要
T cells are potent at eliminating pathogens and playing a crucial role in the adaptive immune response. T cell receptor (TCR) convergence describes T cells that share identical TCRs with the same amino acid sequences but have different DNA sequences due to codon degeneracy. We conducted a systematic investigation of TCR convergence using single-cell immune profiling and bulk TCRβ-sequence (TCR-seq) data obtained from both mouse and human samples and uncovered a strong link between antigen-specificity and convergence. This association was stronger than T cell expansion, a putative indicator of antigen-specific T cells. By using flow-sorted tetramer + single T cell data, we discovered that convergent T cells were enriched for a neoantigen-specific CD8 + effector phenotype in the tumor microenvironment. Moreover, TCR convergence demonstrated better prediction accuracy for immunotherapy response than the existing TCR repertoire indexes. In conclusion, convergent T cells are likely to be antigen-specific and might be a novel prognostic biomarker for anti-cancer immunotherapy.
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