胰岛素抵抗
血管舒张
2型糖尿病
胰岛素
内科学
内分泌学
糖尿病
医学
内皮功能障碍
作者
Jaume Padilla,Camila Manrique-Acevedo,Luis A Martinez-Lemus
出处
期刊:American Journal of Physiology-heart and Circulatory Physiology
[American Physiological Society]
日期:2022-11-04
卷期号:323 (6): H1231-H1238
标识
DOI:10.1152/ajpheart.00537.2022
摘要
Insulin resistance in the vasculature is a hallmark of type 2 diabetes (T2D), and blunting of insulin-induced vasodilation is its primary consequence. Individuals with T2D exhibit a marked impairment in insulin-induced dilation in resistance arteries across vascular beds. Importantly, reduced insulin-stimulated vasodilation and blood flow to skeletal muscle limits glucose uptake and contributes to impaired glucose control in T2D. The study of mechanisms responsible for the suppressed vasodilatory effects of insulin has been a growing topic of interest for not only its association with glucose control and extension to T2D but also its relationship with cardiovascular disease development and progression. In this mini-review, we integrate findings from recent studies by our group with the existing literature focused on the mechanisms underlying endothelial insulin resistance in T2D.
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