区域选择性
化学
肟
烯烃
组合化学
试剂
反应性(心理学)
功能群
有机化学
催化作用
医学
病理
替代医学
聚合物
作者
Yu Zheng,Zhujun Wang,Zhipeng Ye,Kai Tang,Zhenzhen Xie,Jun‐An Xiao,Hao-Yue Xiang,Kai Chen,Xiaoqing Chen,Hua Ye
标识
DOI:10.1002/anie.202212292
摘要
Abstract A metal‐free photosensitized protocol for regioselective diamination of alkene feedstocks over a single step was developed based on the rationally designed bifunctional diamination reagent, thus affording a range of differentially protected 1,2‐diamines in moderate to high yields. Mechanistic studies reveal that the reaction is initiated with a triplet‐triplet energy transfer between thioxanthone catalyst and diamination reagent, followed by fragmentation to simultaneously generate long‐lived iminyl radical and transient amidyl radical. The excellent regioselectivity presumably stems from the large reactivity difference between two different N ‐centered radical species. This protocol is characterized by excellent regioselectivity, broad functional group tolerance, and mild reaction conditions, which would enrich the diversity and versatility of facilitate the diversity‐oriented synthesis of 1,2‐diamine‐containing complex molecule scaffolds.
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