癌症研究
生物
多发性骨髓瘤
PI3K/AKT/mTOR通路
细胞生物学
化学
信号转导
免疫学
作者
Phyllis S.Y. Chong,Jing-Yuan Chooi,Julia S.L. Lim,Aaron C.Y. Leow,Sabrina Hui Min Toh,Irfan Azaman,Mun Yee Koh,Phaik Ju Teoh,Tuan Zea Tan,Tae‐Hoon Chung,Wee Joo Chng
出处
期刊:Cancer Research
[American Association for Cancer Research]
日期:2023-07-18
卷期号:83 (20): 3414-3427
被引量:13
标识
DOI:10.1158/0008-5472.can-22-3481
摘要
Aberrant glycolysis driven by NSD2-mediated upregulation of PKCα can be therapeutically exploited using metabolic inhibitors with lactate as a biomarker to identify high-risk patients who exhibit poor response towards IMiD-based regimens.
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