糖基化
愤怒(情绪)
化学
透明质酸
受体
半胱氨酸
生物化学
生物
遗传学
神经科学
酶
作者
Jing Han,Yu Sun,Ting Wu,Xiaohui Hou,Shaoting Zheng,Haohao Zhang,Tingting Lin,Huijuan Liu,Taolei Sun
出处
期刊:ACS Nano
[American Chemical Society]
日期:2023-07-05
卷期号:17 (14): 14123-14135
被引量:3
标识
DOI:10.1021/acsnano.3c04726
摘要
Glycation is a nonenzymatically catalyzed spontaneous reaction that eventually leads to the formation of advanced glycation end-products (AGEs), which can bind to the receptor for AGEs (RAGE). The consequences are oxidative damage, an inflammatory response, and aging. In this work, we synthesized echinacoside-zinc coordination polymers (ECH-Zn) by using the coordination interaction between the catechol group of ECH and zinc ions. ECH-Zn was further wrapped with hyaluronic acid/poly (ethylenimine) (HA-PEI) to obtain spherical nanoparticle polymers of HA-PEI-coated ECH-Zn (PPZn). PPZn can enhance the uptake and utilization of ECH-Zn and also have a better antiglycation effect in the skin under the effect of promoting transdermal absorption of HA-PEI. Mechanistic studies at the cellular level showed that MDM2 can interact with STAT2 to form a transcriptional complex and thus promote RAGE transcriptional activation. In vitro and in vivo studies revealed that PPZn can decrease the expression and inhibit the interaction of the MDM2/STAT2 complex. It inhibited the function of the MDM2/STAT2 complex and suppressed the transcriptional activation of RAGE, thereby exerting antiglycation effects. In conclusion, this work provides a nanomaterial and elucidated a mechanism of anti-skin glycation.
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