启动(农业)
细胞毒性T细胞
T细胞
生物
多克隆抗体
免疫系统
癌症研究
免疫学
单克隆抗体
抗原
抗体
体外
生物化学
植物
发芽
作者
Hatsuo Aoki,Mikiya Tsunoda,Haru Ogiwara,Haruka Shimizu,Haruka Abe,Tatsuro Ogawa,Takaya Abe,Shigeyuki Shichino,Kouji Matsushima,Satoshi Ueha
出处
期刊:Cancer immunology research
[American Association for Cancer Research]
日期:2023-05-02
卷期号:11 (6): 847-862
被引量:1
标识
DOI:10.1158/2326-6066.cir-22-0517
摘要
The repertoire of tumor-infiltrating T cells is an emerging method for characterizing effective antitumor T-cell responses. Oligoclonal expansion of the tumor T-cell repertoire has been evaluated; however, their association with antitumor effects is unclear. We demonstrate here that the polyclonal fraction of the tumor-reactive T-cell repertoire, consisting of relatively minor clones, increased in tumor-bearing mice treated with monoclonal anti-programmed death-ligand 1 (PD-L1) or anti-CD4, which correlated with antitumor effects. Meanwhile, the size of the oligoclonal fraction consisting of major clones remained unchanged. Moreover, the polyclonal fraction was enriched in progenitor exhausted T cells, which are essential for a durable antitumor response, and was more dependent on CCR7+ migratory dendritic cells, which are responsible for priming tumor-reactive T cells in the tumor-draining lymph nodes. These results suggest that the expansion of diverse tumor-reactive clones ("clonal spreading") represents characteristics of antitumor T-cell responses induced by anti-CD4 and anti-PD-L1 treatment.
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