光动力疗法
线粒体
超氧化物
化学
红灯
癌症研究
医学
乳腺癌
癌症
内科学
生物
生物化学
植物
有机化学
酶
标识
DOI:10.1016/j.jphotochem.2022.114196
摘要
Mitochondria are important regulators of many cellular functions and are considered to be one of the most important subcellular organelles for targeting and delivering photosensitizers due to their high sensitivity to reactive oxygen species (ROS). Herein, we designed and synthesized two novel based aminophenoxazinone D-A-π-A photosensitizers (PVPC-1 and PVPC-6), which have satisfactory photostable and high absorption coefficients in the near-infrared (NIR) region. PVPC-6 has excellent mitochondrial targeting ability, and can efficiently generate superoxide radical (O2•-) inside mitochondria after red light irradiation, which trigger cancer cell apoptosis.
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