Recent advance in diagnoses and treatments of childhood medulloblastoma

Medulloblastoma (MB) is one of the most common childhood malignant tumors in the central nervous system, which accounted for 15%-25% of childhood intracranial tumors. The most common origin location of MB is at the middle line of the posterior cranial fossa. And, MB could usually invade into the cerebellar hemisphere, the fourth ventricle and the brainstem. According to the classification criterion of central nervous system tumor in 2016, MB was classified as class IV tumor. In recent years, with the development of histology and molecular biology techniques, classifications of MB were gradually refined, and MB of different types have different clinical outcomes. At the same time, the researchers and clinical workers are still continuously exploring new and effective treatment methods, making important breakthroughs. This article will systematically elaborate the progress of the clinical diagnoses and treatments, which might provide some useful theoretical references for diagnoses and treatments of childhood MB. Key words: Childhood medulloblastoma; Diagnosis; Treatment