四斯潘宁
跨膜蛋白
蛋白质家族
信号转导
生物
细胞生物学
运动性
跨膜结构域
细胞
氨基酸
生物化学
受体
基因
作者
Lei Wang,Yang Yu,Jing Bai,Yan Jin,Chunyu Zhang,Songbin Fu
出处
期刊:Int J Genet
日期:2012-12-15
卷期号:35 (06): 312-316
标识
DOI:10.3760/cma.j.issn.1673-4386.2012.06.003
摘要
The protein encoded by TSPAN12 is a member of the tetraspanin family.The tetraspanin protein family contains 33 mamalian members.Most of these members are cell-surface proteins that are featured by specific conserved amino acids and specific structure,including 4 transmembrane hydrophobic domains.The proteins mediate signal transduction events that play a role in the regulation of cell development,activation,growth and motility.Its main binding partner is the ADAM 10 protein,and it also binds to the MT1-MMP metalloprotease protein,suggesting TSPAN 12 play an important role in tumor progression.
Key words:
TSPAN12 ; ADAM10 ; MT1-MMP ; Invasion and metastasis
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