Anatomical and electrophysiological analysis of cholinergic inputs from the parabigeminal nucleus to the superficial superior colliculus

The modulatory role of the cholinergic inputs from the parabigeminal nucleus in the visual responses in the superficial superior colliculus (sSC) remains unknown. Here we report that the cholinergic projections terminate densely in the medial sSC and optogenetic manipulations of the cholinergic inputs affect the looming-evoked response and enhance surround inhibition in the sSC. Our data suggest that cholinergic inputs to the sSC contribute to the visual detection of predators.