代谢组
微生物群
双歧杆菌
失调
新陈代谢
肠道菌群
脂质代谢
拟杆菌
酒
氧化应激
化学
代谢组学
生物
细菌
生物化学
乳酸菌
生物信息学
发酵
遗传学
色谱法
作者
Yan Liu,Yakun Luo,Xinghua Wang,Liyong Luo,Kang Sun,Liang Zeng
标识
DOI:10.1021/acs.jafc.0c01947
摘要
This study investigated the protective effects of pu-erh tea extract (PTE) on alcohol-induced microbiomic and metabolomic disorders. In chronic alcohol-exposed mice, PTE ameliorated chronic alcoholic consumption-induced oxidative stress, inflammation, lipid accumulation, and liver and colon damage through modulating microbiomic and metabolomic responses. PTE restored the alcohol-induced fecal microbiota dysbiosis by elevating the relative abundance of potentially beneficial bacteria, for example, Bifidobacterium and Allobaculum, and decreasing the relative abundance of potentially harmful bacteria, for example, Helicobacter and Bacteroides. The alcohol-induced metabolomic disorder was modulated by PTE, which was characterized by regulations of lipid metabolism (sphingolipid, glycerophospholipid, and linoleic acid metabolism), amino acid metabolism (phenylalanine and tryptophan metabolism), and purine metabolism. Besides, the bacterial metabolites of phytochemicals in PTE might contribute to the protective effects of PTE. Overall, PTE could be a functional beverage to treat chronic alcohol consumption-induced microbiomic and metabolomic disorders.
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