配体（生物化学）
医学
生物
化学
计算生物学
药理学
受体
遗传学
作者
Claire Gorby,Junel Sotolongo Bellón,Stephan Wilmes,Walid Warda,Elizabeth Pöhler,Paul K. Fyfe,Adeline Cozzani,Christophe Ferrand,Mark R. Walter,Suman Mitra,Jacob Piehler,Ignacio Moraga
出处
期刊：Science Signaling
[American Association for the Advancement of Science]
日期：2020-09-15
卷期号：13 (649)
被引量：83
标识
DOI：10.1126/scisignal.abc0653
摘要
T cells. Moreover, CAR-modified T cells expanded with the engineered IL-10 variant displayed superior cytolytic activity than those expanded with wild-type IL-10. Our study provides insights into how IL-10 receptor complex stability fine-tunes IL-10 biology and opens new opportunities to revitalize failed IL-10 therapies.
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