免疫组织化学
瑞士/瑞士法郎
病理
ARID1A型
医学
蛋白质亚单位
胃肠道
染色
生物
SMARCB1型
癌症研究
转录因子
SMARCA4型
染色质重塑
突变
遗传学
基因
生物化学
作者
Klaudia M. Nowak,Runjan Chetty
标识
DOI:10.1053/j.semdp.2020.11.001
摘要
The SWItch Sucrose non-fermentable (SWI/SNF) complex is a large, multi-subunit ATP-dependent nucleosome remodeling complex that acts as a tumor suppressor by modulating transcription. Mutations of SWI/SNF subunits have been described in relation to developmental disorders, hereditary SWI/SNF deficiency syndromes, as well as malignancies. In this review we summarize the current literature in regards to SWI/SNF-deficient tumors of the luminal gastrointestinal tract (GIT) and pancreas. As a group they range from moderately to undifferentiated tumors composed of monotonous anaplastic cells, prominent macronucleoli and a variable rhabdoid cell component. Deficiency of a SWI/SNF subunit is typified by complete loss of nuclear staining by immunohistochemistry for respective subunit.
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