赛马鲁肽
恩帕吉菲
医学
2型糖尿病
二甲双胍
中止
随机对照试验
糖尿病
内科学
胃肠病学
泌尿科
利拉鲁肽
内分泌学
作者
Helena W. Rodbard,Julio Rosenstock,Luís Henrique Santos Canani,Chaicharn Deerochanawong,Janusz Gumprecht,Søren Lindberg,Ildiko Lingvay,ANETTE L. SØNDERGAARD,Marianne Bach Treppendahl,Eduard Montanya,PIONEER 2 Investigators,Pablo Jordão Alcântara Cruz,Luis De Loredo,Cecilia Luquez,Maria Alejandra Moisello,Gustavo Akerman Augusto,Marise Lazaretti Castro,Luís Henrique Santos Canani,Branko Akrap,Tomislav Bulum
出处
期刊：Diabetes Care
[American Diabetes Association]
日期：2019-09-17
卷期号：42 (12): 2272-2281
被引量：430
摘要
Oral semaglutide was superior to empagliflozin in reducing HbA1c but not body weight at 26 weeks in patients with type 2 diabetes uncontrolled on metformin. At week 52, HbA1c and body weight (trial product estimand) were significantly reduced versus empagliflozin. Oral semaglutide was well tolerated within the established safety profile of GLP-1 receptor agonists.
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