化学
催化作用
乌尔曼反应
偶联反应
芳基
组合化学
胺气处理
卤代芳基
配体(生物化学)
卤化物
溶剂
有机化学
钯
生物化学
受体
烷基
作者
Chao Zhang,Zha‐Jun Zhan,Min Lei,Lihong Hu
出处
期刊:Tetrahedron
[Elsevier]
日期:2014-11-01
卷期号:70 (46): 8817-8821
被引量:17
标识
DOI:10.1016/j.tet.2014.10.014
摘要
A facile and efficient method for Ullmann-type C–N coupling reaction of amine and aryl halide catalyzed by CuI/metformin in EtOH is described. The advantages of this method are the use of an inexpensive and readily available catalyst and ligand, easy workup, shorter reaction time, improved yields, and the use of green solvent. Furthermore, this procedure is applied successfully for the modification of natural products, such as Vindoline and Tabersonin.
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