Synthesis of the Fungal Lipo‐Chitooligosaccharide Myc‐IV (C16:0, S), Symbiotic Signal of Arbuscular Mycorrhiza

Abstract A new synthesis of the fungal lipo‐chitooligosaccharide Myc‐IV (C16:0, S), which was recently reported to be a major symbiotic signalling molecule in arbuscular mycorrhiza, is described. Key steps include the oxidative cleavage of a 4,6‐ O ‐benzylidene acetal to prepare a disaccharidic glycosyl acceptor, and stereoselective glycosylations with 2‐methyl‐5‐ tert ‐butylphenyl thioglycosyl donors.