Structural insights into substrate specificity and solvent tolerance in alcohol dehydrogenaseADH-‘A’ from Rhodococcus ruber DSM 44541

The structure of the alcohol dehydrogenase ADH-'A' from Rhodococcus ruber reveals possible reasons for its remarkable tolerance to organic co-solvents and suggests new directions for structure-informed mutagenesis to produce enzymes of altered substrate specificity or improved selectivity.