粪肠球菌
氧化应激
毒力
活性氧
发病机制
微生物学
生物
肠球菌
氧化磷酸化
抗生素
细菌
免疫学
基因
生物化学
金黄色葡萄球菌
遗传学
作者
Tomáš Szemes,Barbora Vlková,Gabriel Minárik,Ľubomíra Tóthová,Hana Drahovská,Ján Turňa,Peter Celec
出处
期刊:Redox Report
[Informa]
日期:2010-10-01
卷期号:15 (5): 202-206
被引量:15
标识
DOI:10.1179/135100010x12826446921581
摘要
Enterococci cause serious infections due to a number of virulence factors and wide-spread antibiotic resistance. A molecular mechanism involved in the pathogenesis of enterococcal infections is oxidative stress. Enterococcus faecalis produces a variety of antioxidative enzymes involved in the oxidative stress response, a process that is regulated by several transcriptional regulators. In addition, direct production of free radicals derived from oxygen has been proved and hypothesized, respectively, to contribute to the pathogenesis of colorectal cancer and periodontitis. The understanding of molecular mechanisms behind the production of free radicals and the antioxidative status in E. faecalis might suggest new alternatives for the treatment of enterococcal infections and related diseases.
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