Nanostructured membranes based on cellulose acetate obtained by electrospinning, part 1: Study of the best solvents and conditions by design of experiments

Abstract The electrospinning of cellulose acetate (CA) was investigated to develop biodegradable nanostructured membranes for the controlled release of drugs used to treat skin wounds. CA nanofibers were successfully prepared via the electrospinning in the four mixed solvents acetic acid : water; acetone : water; DMAc : acetone; DMAc : acetone : water. Design of experiments (DOE) was applied to see what combinations of parameters could affect the production of electrospun microfibers and nanofibers to optimize the process. The results of this work indicated that both the processing parameters and the solvent mixtures were responsible for the fiber diameter and nanostructure membrane appearance. The optimized condition for each solvent mixture was obtained and compared with each one of the others. The best conditions achieved were dimethylacetamida (DMAc) : acetone with 17% of CA, which provided homogeneous and free bead fibers with an average diameter of 295 nm. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012