瘦素
星形胶质细胞
小鼠苗条素受体
生长素
下丘脑
内分泌学
受体
生物
内科学
神经科学
中枢神经系统
医学
肥胖
作者
Jae Geun Kim,Shigetomo Suyama,Marco Koch,Sung‐Ho Jin,Pilar Argente-Arizón,Jesús Argente,Zhongwu Liu,Marcelo R. Zimmer,Jin Kwon Jeong,Klara Szigeti‐Buck,Yuanqing Gao,Cristina García‐Cáceres,Chun-Xia Yi,Natalina Salmaso,Flora M. Vaccarino,Julie A. Chowen,Sabrina Diano,Marcelo O. Dietrich,Matthias H. Tschöp,Tamás L. Horváth
摘要
We found that leptin receptors were expressed in hypothalamic astrocytes and that their conditional deletion led to altered glial morphology and synaptic inputs onto hypothalamic neurons involved in feeding control. Leptin-regulated feeding was diminished, whereas feeding after fasting or ghrelin administration was elevated in mice with astrocyte-specific leptin receptor deficiency. These data reveal an active role of glial cells in hypothalamic synaptic remodeling and control of feeding by leptin.
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