蛋白质水解
生物
卡林
后期促进复合物
F盒蛋白
Skp1型
细胞生物学
泛素
细胞分裂控制蛋白4
细胞周期
泛素连接酶
细胞周期进展
后期
细胞
遗传学
生物化学
基因
酶
标识
DOI:10.1016/s0955-0674(98)80119-1
摘要
Progression through the cell cycle requires the activity of two ubiquitination complexes, the Skp1-cullin-F-box-protein complex (SCF) and the anaphase-promoting complex/cyclosome (APC). Observations in the past year have revealed unexpected similarities between the SCF and the APC and have allowed detailed insight into the regulation of their activities. Both complexes are now known to exist in different forms that target different substrates for ubiquitin-dependent proteolysis.
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