果糖
非酒精性脂肪肝
胰岛素抵抗
玉米糖浆
血脂异常
高果糖玉米糖浆
脂肪肝
医学
蔗糖
内科学
膳食蔗糖
代谢综合征
糖
内分泌学
肥胖
食品科学
疾病
生物
作者
Miriam B. Vos,Joel E. Lavine
出处
期刊:Hepatology
[Wiley]
日期:2013-05-01
卷期号:57 (6): 2525-2531
被引量:259
摘要
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in adults and children. A number of genetic and environmental factors are known to predispose individuals to NAFLD. Certain dietary sugars, particularly fructose, are suspected to contribute to the development of NAFLD and its progression. The increasing quantity of fructose in the diet comes from sugar additives (most commonly sucrose and high fructose corn syrup) in beverages and processed foods. Substantial links have been demonstrated between increased fructose consumption and obesity, dyslipidemia, and insulin resistance. Growing evidence suggests that fructose contributes to the development and severity of NAFLD. In human studies, fructose is associated with increasing hepatic fat, inflammation, and possibly fibrosis. Whether fructose alone can cause NAFLD or if it serves only as a contributor when consumed excessively in the setting of insulin resistance, positive energy balance, and sedentary lifestyle is unknown. Sufficient evidence exists to support clinical recommendations that fructose intake be limited through decreasing foods and drinks high in added (fructose-containing) sugars.
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