自愈水凝胶
生物相容性
组织工程
高分子
化学
材料科学
原位
细胞包封
生物医学工程
生物组织
纳米技术
高分子化学
生物化学
有机化学
医学
冶金
作者
Parinaz Nezhad‐Mokhtari,Marjan Ghorbani,Leila Roshangar,Jafar Soleimani Rad
标识
DOI:10.1016/j.ijbiomac.2019.08.047
摘要
Newly, injectable hydrogels have been renowned as promising biomaterials and appropriate candidates for tissue engineering which can be applied for the development of 3-dimensional cell culture models. Hydrogels have in situ formability that allows an actual and homogeneous drugs/cells encapsulation, and suitable for in vivo surgical operation in a minimally invasive way, causing less discomfort for patients. A wide and varied range of methods has been applied to design hydrogels-based biological macromolecules via chemical gelling techniques, such as photo-polymerization, and enzyme-catalyzed reactions due to the biocompatibility and feasible processing of in situ formation of hydrogels and the easy implantation through in situ injection of hydrogels-based biological macromolecules. This present review covers the current advances in the development of injectable hydrogels through enzymatically and photo-crosslinking procedures for tissue engineering. The characteristics and applications of natural and synthetic base materials used in hydrogel generation are also reviewed with an outline on biomedical considerations.
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