胸腺细胞
生物
人口
过继性细胞移植
T细胞
细胞生物学
免疫学
T淋巴细胞
舱室(船)
男科
抗原
免疫系统
医学
环境卫生
海洋学
地质学
作者
Kevin Joannou,Dominic P. Golec,Haiguang Wang,Laura M Henao-Caviedes,Julia May,Rees G. Kelly,R Chan,Stephen C. Jameson,Troy A. Baldwin
出处
期刊:Journal of Immunology
[The American Association of Immunologists]
日期:2022-05-01
卷期号:208 (9): 2131-2140
被引量:3
标识
DOI:10.4049/jimmunol.2100360
摘要
Several unique waves of γδ T cells are generated solely in the fetal/neonatal thymus, whereas additional γδ T cell subsets are generated in adults. One intriguing feature of γδ T cell development is the coordination of differentiation and acquisition of effector function within the fetal thymus; however, it is less clear whether this paradigm holds true in adult animals. In this study, we investigated the relationship between maturation and thymic export of adult-derived γδ thymocytes in mice. In the Rag2pGFP model, immature (CD24+) γδ thymocytes expressed high levels of GFP whereas only a minority of mature (CD24-) γδ thymocytes were GFP+ Similarly, most peripheral GFP+ γδ T cells were immature. Analysis of γδ recent thymic emigrants (RTEs) indicated that most γδ T cell RTEs were CD24+ and GFP+, and adoptive transfer experiments demonstrated that immature γδ thymocytes can mature outside the thymus. Mature γδ T cells largely did not recirculate to the thymus from the periphery; rather, a population of mature γδ thymocytes that produced IFN-γ or IL-17 remained resident in the thymus for at least 60 d. These data support the existence of two populations of γδ T cell RTEs in adult mice: a majority subset that is immature and matures in the periphery after thymic emigration, and a minority subset that completes maturation within the thymus prior to emigration. Additionally, we identified a heterogeneous population of resident γδ thymocytes of unknown functional importance. Collectively, these data shed light on the generation of the γδ T cell compartment in adult mice.
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