Can intermittent fasting help in stem-cell rejuvenation?

Background: Human tissues are sustained by stem cells, the balance between stem cell self-renewal and differentiation, and cell death is the crucial element of haemostasis, which plays a vital role in tissue remodelling. Stem cell therapy is recognized as regenerative medicine. We can stimulate stem cell growth/regeneration through various events. Objectives: In this review, we illustrate whether fasting can stimulate stem cell regeneration. Methodology: A literature survey was undertaken to gather recent research and address the effects of fasting on stem cell renewal, which was the review's purpose. Results: Enterocytes in drosophila were restored after exposure to the dietary restriction. As the result, fasting before etoposide exposure safeguarded mice against harm caused by etoposide when compared with the fed group. A study conducted on the effects of periodic fasting in yeast, mice, and humans shows the increase in lifespan and stress resistance of yeast fasting reduces the risks due to age factors and diseases like diabetes, cardiovascular diseases and promotes a healthy life span of mice and human. Conclusion: Dietary limitations will be used in conjunction with the existing therapeutic approach as adjuvant therapy. It will be a more effective treatment. Fasting has the potential to protect against the negative effects of chemotherapy while also boosting stem cell regeneration, according to preclinical findings. Even though regenerative medicine and stem cell therapy are still in their embryonic stage, greater interventions are needed to show the target pathway of fasting in stem cell renewal. Keywords: Fasting, stem cell regeneration, emerging therapy.