산화적 스트레스를 유발시킨 HepG₂ 세포에서 국내산 로열젤리의 항산화 효과

Antioxidant has known to effectively remove reactive oxygen species (ROS) which are regarded as a source of many types of diseases. In modern diets, the use of royal jelly (RJ) has more increased because of the trend toward the use of functional foods and dietary supplements. We investigated antioxidant effect of Korean royal jelly in oxidative stress induced HepG2 cell. The antioxidant activity was evaluated by means of DPPH free radical scavenging, thiobarbituric acid reactive substance (TBARS) products, and superoxide dismutase (SOD) and catalase activity assays. HepG2 cells treated with RJ at 100, 200, 500?g/ml significantly increased the DPPH scavenging activity in a dose-dependent manner. Also, the RJ significantly reduced the TBARS levels and increased the SOD activity compared to those of the control group. These results suggest that Korean RJ could be antioxidant functional food with high free radical scavenging activity and antioxidant capacity.