Overview of Safety Assessment and Toxicological Screening of Dermal Formulations

The skin is one of our largest organs and the delivery of drugs via the skin is gorgeous and also challenging vicinity in research.The dermal formulations are used for cosmetic and therapeutic purposes by various age groups.Hence, the safety data are essential for these preparations and required long-term toxicity testing is essential to prevent delayed effects on users/consumers.In recent years, use of dermal preparations including cosmetic products has ever increased globally which exhibiting potential health risks including mild hypersensitivity and lethal intoxication.Hence, testing any formulation including dermal preparations for its toxicity is the basic requirement in most toxicological frameworks.Moreover, many of the dermal preparations are available over-the-counter.Hence, the data on the safety of these preparations are very essential, which can be studied using preclinical models, preferably using cell lines or animals.The purpose of the current review is to summarize the toxicity testing methods for dermal preparations.