蒽醌
化学
光动力疗法
配体(生物化学)
光化学
辐照
光催化
光毒性
光解
催化作用
光催化
红灯
组合化学
立体化学
受体
有机化学
生物化学
体外
物理
生物
核物理学
植物
作者
Chao Zhang,Xusheng Guo,Xuwen Da,Zhaoyi Wang,Xuesong Wang,Qianxiong Zhou
出处
期刊:Dalton Transactions
[The Royal Society of Chemistry]
日期:2021-01-01
卷期号:50 (31): 10845-10852
被引量:13
摘要
Phototherapy for cancer treatment has received much attention in recent years, and compounds with multiple anticancer mechanisms upon irradiation are particularly appealing. In this work, a nitro-anthraquinone group was attached to a biq (2,2'-biquinoline) ligand based Ru(ii) complex, endowing the resultant Ru1 compound with multiple anticancer mechanisms upon 600 nm light irradiation. Ru1 can undergo biq ligand photodissociation, showing its potential as a photoactivated chemotherapy (PACT) agent. Moreover, a Ru(iii) centre and an anthraquinone anion centre may be generated upon irradiation, which can further oxidize NADH/NADPH and generate O2˙-, successfully eliciting photoredox catalysis and photodynamic therapy (PDT). Compared to the control complex Ru2 without the nitroanthraquinone group, Ru1 exhibited much enhanced photocytotoxicity towards a series of cancer cell lines and 3D multicellular spheroids upon red light irradiation.
科研通智能强力驱动
Strongly Powered by AbleSci AI