破骨细胞
骨质疏松症
骨重建
骨吸收
氧化磷酸化
糖酵解
机制(生物学)
三磷酸腺苷
能量代谢
化学
新陈代谢
内科学
内分泌学
医学
细胞生物学
生物
生物化学
认识论
哲学
受体
作者
Wacili Da,Tao Lin,Yuyan Zhu
标识
DOI:10.3389/fendo.2021.675385
摘要
In recent decades, the mechanism underlying bone metabolic disorders based on energy metabolism has been heavily researched. Bone resorption by osteoclasts plays an important role in the occurrence and development of osteoporosis. However, the mechanism underlying the osteoclast energy metabolism disorder that interferes with bone homeostasis has not been determined. Bone resorption by osteoclasts is a process that consumes large amounts of adenosine triphosphate (ATP) produced by glycolysis and oxidative phosphorylation. In addition to glucose, fatty acids and amino acids can also be used as substrates to produce energy through oxidative phosphorylation. In this review, we summarize and analyze the energy-based phenotypic changes, epigenetic regulation, and coupling with systemic energy metabolism of osteoclasts during the development and progression of osteoporosis. At the same time, we propose a hypothesis, the compensatory recovery mechanism (involving the balance between osteoclast survival and functional activation), which may provide a new approach for the treatment of osteoporosis.
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