化学
催化作用
铜
组合化学
药物化学
有机化学
三氟甲基化
作者
Wangqin Ji,Haihong Wu,Wenbo Li,Junliang Zhang
摘要
A novel, simple, effective and rapid synthetic method to construct the C-2 trifluoromethylated indolinyl ketones via a copper-catalyzed cyclization reaction between N-alkylaniline and β-(trifluoromethyl)-α,β-unsaturated enones was developed. The results of the control experiments show that the reaction may involve a radical mechanism by a single-electron transfer process. Moreover, a broad substrate scope and good functional groups, high diastereoselectivities (dr, up to >20 : 1) as well as gram-scale synthesis make this approach highly attractive.
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