上丘
脑干
神经科学
前脑
心理学
感知
灵长类动物
认知
具身认知
认知心理学
中枢神经系统
计算机科学
人工智能
作者
Elizabeth Jun,Alex Bautista,Michael D. Nunez,Daicia C. Allen,Jung H. Tak,E. Castañón Álvarez,Michele A. Basso
标识
DOI:10.1038/s41593-021-00878-6
摘要
Trained monkeys performed a two-choice perceptual decision-making task in which they reported the perceived orientation of a dynamic Glass pattern, before and after unilateral, reversible, inactivation of a brainstem area—the superior colliculus (SC)—involved in preparing eye movements. We found that unilateral SC inactivation produced significant decision biases and changes in reaction times consistent with a causal role for the primate SC in perceptual decision-making. Fitting signal detection theory and sequential sampling models to the data showed that SC inactivation produced a decrease in the relative evidence for contralateral decisions, as if adding a constant offset to a time-varying evidence signal for the ipsilateral choice. The results provide causal evidence for an embodied cognition model of perceptual decision-making and provide compelling evidence that the SC of primates (a brainstem structure) plays a causal role in how evidence is computed for decisions—a process usually attributed to the forebrain. Unilateral inactivation of the superior colliculus in monkeys reveals that a brainstem structure plays a causal role in how evidence is computed for decisions, a process usually attributed to the forebrain.
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