Conserved and non-served regions in herpes simplex viral glycoproteins for probe designing

Herpes simplex virus (HSV) is one of the infecting human viruses. To achieve the entry of virion into the host cells, HSV requires 5 types of the glycoprotein, which are glycoprotein C (gC), glycoprotein D (gD), Glycoprotein B (gB) and a complex of glycoprotein H and glycoprotein L (gH-gL). All five glycoproteins are mandatory for HSV-host interaction and infection. There will be no invasion to the cells without involvement of these glycoproteins; there will be no cellular invasion. In this paper, we aligned the nucleotide sequences of glycoprotein B and glycoprotein D from herpes simplex types l & 2 virus. By comparing these nucleotide sequences between herpes simplex type l and type 2 viruses, we able to find out the conserved and non-conserved regions, which indicate the similarities and differences between glycoprotein B and glycoprotein D of these two human herpes viruses.