共病
2型糖尿病
多态性(计算机科学)
胰岛素抵抗
糖尿病
遗传倾向
遗传学
基因型
医学
生物
生物信息学
内科学
基因
内分泌学
作者
Anna Shalimova,Г. Д. Фадєєнко,Olena Kolesnikova,Ganna Isayeva,Vira Zlatkina,Valeriya Nemtsova,Kostyantyn Prosolenko,Valentyna Hryhorivna Psarova,N. Kyrychenko,Maryna Kochuieva
标识
DOI:10.2174/1381612825666190314124049
摘要
Background: Hereditary component plays a significant role in the formation of insulin resistance (IR) - one of the pathogenetic links of arterial hypertension (AH) and type 2 diabetes mellitus (DM2). However, the genetic predisposition to IR can not be realized and does not manifest itself clinically in the absence of appropriate factors of the environment (excessive nutrition, low physical activity, etc.). Objective: The review summarizes the results of studies which describe the contribution of genetic polymorphism to the formation and progression of AH, DM2 and their comorbidity in various populations. Results: In many studies, it has been established that genetic polymorphism of candidate genes is influenced by the formation, course and complication of AH and DM2. According to research data, the modulating effect of polymorphism of some genetic markers of AH and DM2 on metabolism and hemodynamics has been established. The results of numerous studies have shown a higher frequency of occurrence of AH and DM2, as well as their more severe course with adverse genetic polymorphisms. At the same time, the role of genetic polymorphism in the formation of AH and DM2 differs in different populations. Conclusion: Contradictory data on the influence of gene polymorphisms on the formation of AH and DM2 in different populations, as well as a small number of studies on the combined effects of several polymorphisms on the formation of comorbidity, determine the continuation of research in this direction.
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