黄芩苷
黄芩
体内
体外
医学
药理学
传统医学
免疫学
生物
化学
中医药
生物化学
生物技术
病理
色谱法
替代医学
高效液相色谱法
作者
Yun Chen,Fangke Yao,Ke Ming,Jintong Shi,Ling Zeng,Deyun Wang,Yi Wu,Yuanliang Hu,Jiaguo Liu
出处
期刊:Current Molecular Medicine
[Bentham Science]
日期:2019-01-01
卷期号:19 (5): 376-386
被引量:8
标识
DOI:10.2174/1566524019666190405095301
摘要
<P>Background: Duck virus hepatitis (DVH) caused by duck hepatitis A virus type 1 (DHAV-1) is a malignant disease in ducklings, causing economic losses in the duck industry. However, there is still no antiviral drug against DHAV-1 in the clinic. </P><P> Objective: Our aim is to investigate the anti-DHAV-1 effect of baicalin, which is a flavonoid derived from the Chinese medicinal herb huangqin (Scutellaria baicalensis Georgi). </P><P> Methods: Here, we first detected its anti-DHAV-1 ability in vitro and in vivo. At the same time, the inhibition of baicalin on DHAV-1 reproduction was determined. Finally, we tested and verified the anti-oxidative and immuno-enhancing roles of baicalin on its curative effect on DVH. </P><P> Results: Baicalin possessed anti-DHAV-1 effect. It improved the cytoactive of DEH which was infected by DHAV-1 as well as reduced the DHAV-1 reproduction in DEH. Under baicalin treatment, mortality of ducklings infected by DHAV-1 decreased, additionally the DHAV-1 level and liver injury in such ducklings were significantly reduced or alleviated. The in vitro mechanism study indicated baicalin inhibited DHAV-1 reproduction via interfering the viral replication and release. Furthermore, the in vivo mechanism study manifested both the anti-oxidative and immuno-enhancing abilities of baicalin, which played crucial roles in its curative effect on DVH. </P><P> Conclusion: This study may provide a scientific basis for developing baicalin as one or a part of the anti-DHAV-1 drugs.</P>
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