化学
谷胱甘肽
抗氧化剂
过氧化氢酶
四溴双酚A
超氧化物歧化酶
活性氧
谷胱甘肽过氧化物酶
氧化应激
生物化学
酶
有机化学
阻燃剂
作者
Monika Jarosiewicz,Anita Krokosz,Agnieszka Marczak,Bożena Bukowska
出处
期刊:Chemosphere
[Elsevier]
日期:2019-07-01
卷期号:227: 93-99
被引量:32
标识
DOI:10.1016/j.chemosphere.2019.04.008
摘要
Currently, more and more concerns are related to oxidative stress appearing in cells as a result of xenobiotics action. It has been found that selected brominated flame retardants (BFRs) can cause reactive oxygen species (ROS) induction at environmental concentrations. Excessive ROS induction can contribute to the redox imbalance in the cell. Therefore, the aim of our work was to evaluate the effect of selected BFRs on the activity of antioxidant enzymes, i.e. superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and the level of reduced glutathione (GSH) in human erythrocytes. Erythrocytes were incubated with tetrabromobisphenol A (TBBPA), tetrabromobisphenol S (TBBPS), 2,4-dibromophenol (2,4-DBP), 2,4,6-tribromophenol (2,4,6-TBP) and pentabromophenol (PBP) in the concentration ranging from 1 to 100 μg/ml. This study has shown that the BFRs studied disturbed redox balance in human erythrocytes. TBBPA caused more significant decrease in antioxidant enzymes activities than other compounds examined. Among bromophenols studied, 2,4-DBP most strongly affected antioxidant system, which indicated that the number of bromine atoms in the molecule did not significantly affect the pro-oxidative properties of the BFRs examined.
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