Objective To compare the clinical effect and safety of microendoscopic discectomy and fenestration discectomy in treatment of patients with lumbar disc herniation. Methods The medical data of 80 patients performed surgery for lumbar disc herniation were retrospectively analyzed. Forty-two patients in trial group were performed with microendoscopic discectomy,while the remaining patients( control group) were given with fenestration discectomy. The effects of surgery in patients of these 2 groups were compared with each other in such parameters as length of incision,operating time,amount of blood loss,curative effect and incidence rate of complications. Results The length of incision,operating time and amount of blood loss in trial group were less than those of control group respectively( P 0. 05). There was no statistically difference in curative effect( Z =-0. 696,P = 0. 486). All patients in these 2 groups got primary healing in operative incisions and no complications such as injury of nerve root,disc space infection and epidural hematoma were found. Conclusion The therapeutic effect and safety of microendoscopic discectomy is similar to that of fenestration discectomy in treatment of lumbar disc herniation,while the former has the advantages of less invasiveness,shorter operating time and less blood loss.