Release behavior of polyethylene glycol mono-4-nonylphenyl ether from ethyl cellulose films

Objective To investigate release behavior of amphiphilic polyethylene glycol mono-4-nonylphenyl ether from water-insoluable polymer ethyl cellulose,and the effect on release behavior when water semi-soluable cationic surfactant hexadecyltrimethyl ammonium bromide was added.Methods Five kinds of drug-loaded ethyl cellulose film were prepared by casting method with mass ratio of polyethylene glycol mono-4-nonylphenyl ether/ethyl cellulose at 1.5∶ 10.0,5.0∶ 10.0,10.0∶ 10.0,20.0∶ 10.0,40.0∶ 10.0,respectively.Another 3 kinds film with hexadecyltrimethyl ammonium bromide were prepared wiht the ratio of polyethylene glycol mono-4-nonylphenyl ether/hexadecyltrimethyl ammonium bromide /ethyl cellulose at 1.5∶ 0.5∶ 10.0,1.5∶ 1.0∶ 10.0,5.0∶ 0.5∶ 10.0,5.0∶ 1.0∶ 10.0,10.0∶ 0.5∶ 10.0,10.0∶ 1.0∶ 10.0.Drug release test was carried out at 37 ℃,120 r · min-1 in deionized water,release amount was determined by HPLC before accumulative release profiles were prepared and regressed within 8 h.Results Loading amount of polyethylene glycol mono-4-nonylphenyl ether in ethyl cellulose film could lead no drug release within 8h or total burst release after 30 min,2 series of films had the ability of sustained release and as the loading amount of drug lifted,drug release amount became bigger at the same sampling time.Addition of trimethylhexadecyl ammonium bromide favored the release of the drug.Drug release profiles of films which release drug sustainably fitted the regress of Higuchi′s equation and 1st order release equation well.Conclusions Loading amount of polyethylene glycol mono-4-nonyl phenyl ether in ethyl cellulose can affect the release behavior of itself and addition of trimethylhexadecyl ammonium bromide can accelerate the release of the drug.This research provides some references of release behavior for other polyethylene glycol mono-4-nonylphenyl ether/ethyl cellulose hybrid systems.