Protein Tyrosine Phosphatase 1B and Insulin Signal Transduction

Protein tyrosine phosphatase 1B(PTP-1B)is the negative regulatory factoes in insulin signal transduction,which can inhibit the insulin signal transduction pathway by dephosphorylating the phosphotyrosine of many signal protein such as insulin receptor and its substrate.Its negative regulatory effect has tissue specificity,and many factors can affect its catalytic activity.Besides that,PTP-1B also has intercoordination with other protein-tyrosine-phosphatase in insulin signal transduction pathway.Because of the close relationship between PTP-1B and metabolic diseases such as diabeted type 2,obesity and so on,Developing small-molecule PTP-1B inhibitors will provide new idea to prevent and treat this kind of disease.